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MOTS-C

MOTS-C

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MOTS-C is a mitochondrial-derived research peptide studied in laboratory models involving cellular energy regulation, metabolic signaling, and adaptive stress-response pathways. Supplied as a clearly labeled 10 mg lyophilized research material.

Choose one vial or save 10% with a three-vial option. Variant-specific analytical documentation can be viewed through the COA section when available.

For laboratory research use only.

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Research overview

A mitochondrial signal with cellular reach.

MOTS-C is encoded by a short open reading frame within mitochondrial 12S rRNA. Published preclinical work examines its roles in metabolic homeostasis, cellular stress responses, and mitonuclear communication.

AMPKA cellular energy-sensing pathway reported in mechanistic and preclinical research.
mtDNAMOTS-C originates from a short open reading frame in the mitochondrial 12S rRNA region.
NucleusStress-responsive nuclear translocation has been studied in cellular models.
Full nameMitochondrial ORF of 12S rRNA-c
Amino acids16
SequenceMRWQEMGYIFYPRKLR
Material formLyophilized powder
Compound Profile & Technical Overview
MOTS-C is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame within the 12S ribosomal RNA region of mitochondrial DNA. Its published sequence is MRWQEMGYIFYPRKLR. Preclinical research has examined MOTS-C in relation to cellular energy sensing, AMPK-associated signaling, skeletal-muscle metabolism, metabolic stress, and communication between mitochondrial and nuclear gene-expression programs. Imagine First supplies a 10MG lyophilized research presentation. Identity, analytical purity, and measured peptide content are documented in the current-batch Purity, ID & Quantitation report.
Storage requirements
Protect from lightKeep refrigerated after reconstitutionAvoid freeze/thaw cycles
Lyophilized powder-20°CStated stability: 24+ months
Reconstituted solution2-8°CStated stability: approximately 30 days

Sealed lyophilized vials are described as heat-stable; refrigeration or freezing of sealed vials is optional. The 2-8°C guidance applies after reconstitution. Always follow the lot-specific documentation when it differs.

Published Research & References
Primary sources: the original Cell Metabolism discovery paper, metabolic-stress and nuclear-translocation research, and preclinical metabolomics and insulin-sensitivity research. Most mechanistic findings are preclinical and should not be interpreted as established human outcomes or product claims.
Important research notice
This material is offered strictly for laboratory research use. It is not intended for human or veterinary use, food use, compounding, diagnosis, treatment, cure, or prevention of disease. Published MOTS-C findings are provided only as educational research context and do not establish equivalence to independently supplied research material.
FOR LABORATORY RESEARCH USE ONLY · NOT FOR HUMAN OR VETERINARY USE · NOT A DRUG, FOOD, COSMETIC, OR MEDICAL PRODUCT