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GLP-3R

GLP-3R

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GLP-3R is a 39-amino-acid triple-receptor research peptide associated with GIP, GLP-1, and glucagon signaling pathways. Supplied in lyophilized form with clearly labeled 10 mg, 15 mg, and 30 mg strengths for controlled laboratory study.

Choose one vial or save 10% with a three-vial option. Variant-specific analytical documentation can be viewed through the COA section when available.

For laboratory research use only.

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Research overview

One molecule. Three signaling pathways.

GLP-3R is associated with the published retatrutide literature, where the compound is identified as LY3437943. The "triple agonist" description refers to activity at three receptor systems—not three separate peptides.

GIPRAn incretin-family receptor involved in nutrient-responsive signaling.
GLP-1RAn incretin-family receptor studied in glucose-dependent, appetite, and gastrointestinal signaling.
GCGRA receptor involved in hepatic and whole-body energy metabolism.
Published nameRetatrutide
Development codeLY3437943
Research classTriple-receptor agonist
StatusInvestigational
Compound Profile & Technical Overview
GLP-3R is associated with retatrutide, identified in published literature by the development code LY3437943. Retatrutide is a single synthetic peptide engineered for agonist activity across three receptor systems: glucose-dependent insulinotropic polypeptide receptor (GIPR), glucagon-like peptide-1 receptor (GLP-1R), and glucagon receptor (GCGR). The term "triple agonist" describes this combined receptor profile within one molecule, not a blend of three separate peptides. Imagine First offers GLP-3R as lyophilized research material in 10MG, 15MG, and 30MG presentations. Available current-batch analytical reports are matched to the applicable product strength and lot. Retatrutide remains an investigational compound, and published clinical findings are presented only as educational research context.
Storage requirements
Protect from lightKeep refrigerated after reconstitutionAvoid freeze/thaw cycles
Lyophilized powder-20°CStated stability: 24+ months
Reconstituted solution2-8°CStated stability: approximately 30 days

Sealed lyophilized vials are described as heat-stable; refrigeration or freezing of sealed vials is optional. The 2-8°C guidance applies after reconstitution. Always follow the lot-specific manufacturer documentation when it differs.

Published Research & References
Read the original sources: Cell Discovery receptor-structure research, NEJM Phase 2 trial, and Phase 1b study on PubMed. Evidence types and limitations are labeled clearly.
Important research notice
This material is offered strictly for laboratory research use. It is not intended for human or veterinary use, food use, compounding, diagnosis, treatment, cure, or prevention of disease. Published studies do not establish equivalence between an independently supplied research material and a clinical-trial product.
FOR LABORATORY RESEARCH USE ONLY · NOT FOR HUMAN OR VETERINARY USE · RETATRUTIDE IS INVESTIGATIONAL AND IS NOT AN FDA-APPROVED DRUG